Elizabeth was possibly the daughter of Thomas Conselah who died in 1739. His will mentions a daughter, Elizabeth Francisco. It is also possible that she was the mother of both John and Thomas.

In 1756 John Sisco petitioned the Kent Co. Orphans Court for custody of his dead brother's child (sex and name unknown). The name of this deceased brother is also not known but his widow was listed as "Catherine". This rules out the deceased Thomas, whose widow was named Patience. This child was living with a family called "Swaney" at the time. John signed the papers with an elaborate, clear hand, indicating that he was a literate man. The records are fragmentary so we can't say for sure if John was living in Kent Co. in 1756 or if he sent the petition via an attorney.

In 1782, we find a John Sisco mentioned in the "Census of the White Population of Delaware", living in Little Creek Hundred. He is also found listed in the 1785 tax lists for Little Creek Hundred.

When John Durham died in 1788, his estate indicated that his daughter, Sarah, was married to John Sisco. Also mentioned in the accounts were Ephraim Sisco. It is highly likely that this was our John Sisco. Remember that, in 1750, John Sisco appeared with Daniel Durham in the accounts of Thomas Sisco. Daniel was either John Durham's son or his brother (see the Durham Family).

The 1790 census lists two John Sisco's, one called "Jr.". The elder Sisco is probably our John. Based on John Sr.'s will, we known that John Sisco the younger was not John Sr.'s son, although he was definitely a relative. This younger John Sisco, Jr. would later marry into the same Durham family.

On 24 October, 1791, in Kent Co., DE, Letters of Administration were granted on the estate of John Sisco. It is highly likely that this refers to John Sr. and it is equally likely that this was Sarah Durham's husband.

The estate records indicate that John was a very well-to-do man. His extensive inventory lists 7 beds & furniture, bolts of cloth, pewter, 5 spinning wheels, Queensware, tables, chairs, BOOKS and lots of farm equipment. The inventory was valued at 942 pounds. Most of the wealth was in livestock. John's son, Charles Francisco signed the administration bond with a clear hand indicating that, like his father, Charles was also a literate man.

Mentioned in John's estate records were a widow (un-named but probably Sarah Durham Sisco) , a son Charles, daughters Esther Francisco and Lydia Francisco and Lydia's daughter, Elizabeth Francisco. No son "John" is mentioned which strongly suggests that the John Jr. from the census records was not the son of this John Sr.

John's estate was not finally settled until 1800. Administration had passed to son Charles and , upon his death in 1798, to daughter Lydia. Lydia also died in 1798, leaving her daughter, Elizabeth Francisco as the final administrator on the combined estates of her mother, uncle and grandfather.

In 1815 Esther Sisco died. It is believed that this was NOT John's daughter who died c.1810 but it is not clear who this was. Her will mentioned Gelica Lockerman (who later married a HANSOR) and Susan Derham , wife of George Durham. One of the witnesses tothe will was John SANDERS.